The bone metastasis niche in breast cancer-potential overlap with the haematopoietic stem cell niche in vivo.

ABSTRACT:

Background

Bone metastasis is one of the most common complications of advanced breast cancer. During dissemination to bone, breast cancer cells locate in a putative 'metastatic niche', a microenvironment that regulates the colonisation, maintenance of tumour cell dormancy and subsequent tumour growth. The precise location and composition of the bone metastatic niche is not clearly defined. We have used in vivo models of early breast cancer dissemination to provide novel evidence that demonstrates overlap between endosteal, perivascular, HSC and the metastatic niche in bone.

Methods

Estrogen Receptor (ER) +ve and -ve breast cancer cells were labelled with membrane dyes Vybrant-DiD and Vybrant-CM-DiI and injected via different routes in BALBc/nude mice of different ages

SUBMITTER: Allocca G 

PROVIDER: S-EPMC6582079 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature