HPA axis function and diurnal cortisol in post-traumatic stress disorder: A systematic review.

ABSTRACT:

Background

There is inconsistency in the literature regarding the nature of hypothalamic-pituitary-adrenal (HPA) axis functionality in post-traumatic stress disorder (PTSD).

Purpose

The review aimed to investigate HPA axis functionality via the diurnal profile of cortisol as it relates to PTSD.

Methods

The authors conducted a systematic review of the literature from June 2017 - March 2019 in accordance with The PRISMA Statement in the following four databases: PubMed, MEDLINE, ScienceDirect and PsycINFO with Full Text. The search strategy was limited to articles in English language, published in peer-reviewed journals within the last decade and human studies. Search terms included "post-traumatic stress disorder" OR "PTSD", AND "hypothalamic pituitary adrenal axis" OR

SUBMITTER: Speer KE 

PROVIDER: S-EPMC6582238 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature