Endocannabinoids, stress signaling, and the locus coeruleus-norepinephrine system.

ABSTRACT: The endocannabinoid (eCB) system has been implicated in a variety of physiological functions due to abundant expression of its receptors and endogenous ligands in the central nervous system. Substantial progress has been made in understanding how the eCB system influences the brain norepinephrine (NE) system, an important neurochemical target in the continued development of new therapies for stress-induced psychiatric disorders. We, and others, have characterized the neuroanatomical, biochemical and pharmacological effects of cannabinoid receptor modulation on brain noradrenergic circuitry and defined how molecular elements of the eCB system are positioned to directly impact the locus coeruleus (LC)-prefrontal cortex pathway, a neural circuit well recognized for contributing to symptoms of

SUBMITTER: Wyrofsky RR 

PROVIDER: S-EPMC6582240 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature