Dataset Information

Accelerated Age-Related Degradation of the Tectorial Membrane in the Ceacam16^βgal/βgal Null Mutant Mouse, a Model for Late-Onset Human Hereditary Deafness DFNB113.

ABSTRACT: CEACAM16 is a non-collagenous protein of the tectorial membrane, an extracellular structure of the cochlea essential for normal hearing. Dominant and recessive mutations in CEACAM16 have been reported to cause postlingual and progressive forms of deafness in humans. In a previous study of young Ceacam16^βgal/βgal null mutant mice on a C57Bl/6J background, the incidence of spontaneous otoacoustic emissions (SOAEs) was greatly increased relative to Ceacam16^+/+ and Ceacam16^+/βgal mice, but auditory brain-stem responses (ABRs) and distortion product otoacoustic emissions (DPOAEs) were near normal, indicating auditory thresholds were not significantly affected. To determine if the loss of CEACAM16 leads to hearing loss at later ages in

SUBMITTER: Goodyear RJ

PROVIDER: S-EPMC6582249 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Dataset Information

Accelerated Age-Related Degradation of the Tectorial Membrane in the Ceacam16^βgal/βgal Null Mutant Mouse, a Model for Late-Onset Human Hereditary Deafness DFNB113.

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Dataset Information

Accelerated Age-Related Degradation of the Tectorial Membrane in the Ceacam16βgal/βgal Null Mutant Mouse, a Model for Late-Onset Human Hereditary Deafness DFNB113.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Accelerated Age-Related Degradation of the Tectorial Membrane in the Ceacam16^βgal/βgal Null Mutant Mouse, a Model for Late-Onset Human Hereditary Deafness DFNB113.