Non-canonical translation initiation in yeast generates a cryptic pool of mitochondrial proteins.

ABSTRACT: Utilization of non-AUG alternative translation start sites is most common in bacteria and viruses, but it has been also reported in other organisms. This phenomenon increases proteome complexity by allowing expression of multiple protein isoforms from a single gene. In Saccharomyces cerevisiae, a few described cases concern proteins that are translated from upstream near-cognate start codons as N-terminally extended variants that localize to mitochondria. Using bioinformatics tools, we provide compelling evidence that in yeast the potential for producing alternative protein isoforms by non-AUG translation initiation is much more prevalent than previously anticipated and may apply to as many as a few thousand proteins. Several hundreds of candidates are predicted to gain a mitochondrial tar

SUBMITTER: Monteuuis G 

PROVIDER: S-EPMC6582344 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature