Effect of sevoflurane on systemic and cerebral circulation, cerebral autoregulation and CO₂ reactivity.

ABSTRACT:

Background

Sevoflurane is one of the most frequently used inhaled anesthetics for general anesthesia. Previously it has been reported that at clinically used doses of sevoflurane, cerebral vasoreactivity is maintained. However, there are no data how sevoflurane influences systemic and cerebral circulation in parallel. The aim of our study was to assess systemic and cerebral hemodynamic changes as well as cerebral CO₂-reactivity during sevoflurane anesthesia.

Methods

Twenty nine patients undergoing general anesthesia were enrolled. Anesthesia was maintained with 1 MAC sevoflurane in 40% oxygen. Ventilatory settings (respiratory rate and tidal volume) were adjusted to reach and maintain 40, 35 and 30 mmHg EtCO₂ for 5 min respectively. At the end of each p

SUBMITTER: Juhasz M 

PROVIDER: S-EPMC6582518 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature