Effect of PEEP and I:E ratio on cerebral oxygenation in ARDS: an experimental study in anesthetized rabbit.

ABSTRACT:

Background

Although PEEP and inversed I:E ratio have been shown to improve gas exchange in ARDS, both can adversely affect systemic hemodynamics and cerebral perfusion. The goal of this study was to assess how changes in PEEP and I:E ratio affect systemic and cerebral oxygenation and perfusion in normal and injured lung.

Methods

Eight anesthetized Chinchilla-Bastard rabbits were ventilated at baseline with pressure-regulated volume control mode, V_T = 6 ml/kg, PEEP = 6 cmH₂O, FIO₂ = 0.4; respiratory rate set for ETCO₂ = 5.5%, and I:E = 1:2, 1:1 or 2:1 in random order. Ultrasonic carotid artery flow (CF), arterial (PaO₂), jugular venous blood gases and near infrared spectroscopic cerebral oxygenation (∆HBO₂) wer

SUBMITTER: Lovisari F 

PROVIDER: S-EPMC6582519 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature