Combined serum biomarkers in the noninvasive diagnosis of complicated parapneumonic effusions and empyema.

ABSTRACT:

Background

We previously demonstrated that the pleural levels of proteins (neutrophil gelatinase-associated lipocalin/NGAL, calprotectin, bactericidal permeability-increasing/BPI, azurocidin 1/AZU-1) were valuable markers for identifying complicated PPE (CPPE). Herein, this study was performed to evaluate whether these proteins are useful as serological markers for identifying CPPE and empyema.

Methods

A total of 137 participates were enrolled in this study. The levels of NGAL, calprotectin, BPI and AZU-1 were measured in serum and pleural fluid by enzyme-linked immunosorbent assay. We also characterized the diagnostic values of these markers between different groups.

Results

The serum levels of NGAL, calprotectin, and BPI in PPE patients were significantly higher tha

SUBMITTER: Wu KA 

PROVIDER: S-EPMC6582530 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature