Oligodendroglial tumours: subventricular zone involvement and seizure history are associated with CIC mutation status.

ABSTRACT:

Background

CIC-mutant oligodendroglial tumours linked to better prognosis. We aim to investigate associations between CIC gene mutation status, MR characteristics and clinical features.

Methods

Imaging and genomic data from the Cancer Genome Atlas and the Cancer Imaging Archive (TCGA/TCIA) for 59 patients with oligodendroglial tumours were used. Differences between CIC mutation and CIC wild-type were tested using Chi-square test and binary logistic regression analysis.

Results

In univariate analysis, the clinical variables and MR features, which consisted 3 selected features (subventricular zone[SVZ] involvement, volume and seizure history) were associated with CIC mutation status (all p < 0.05). A multivariate logistic regression analysis identified that seizure hist

SUBMITTER: Liu Z 

PROVIDER: S-EPMC6582578 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature