Muscle injury-induced hypoxia alters the proliferation and differentiation potentials of muscle resident stromal cells.

ABSTRACT:

Background

Trauma-induced heterotopic ossification (HO) is a complication that develops under three conditions: the presence of an osteogenic progenitor cell, an inducing factor, and a permissive environment. We previously showed that a mouse multipotent Sca1⁺ CD31^- Lin^- muscle resident stromal cell (mrSC) population is involved in the development of HO in the presence of inducing factors, members of the bone morphogenetic protein family. Interestingly, BMP9 unlike BMP2 causes HO only if the muscle is damaged by injection of cardiotoxin. Because acute trauma often results in blood vessel breakdown, we hypothesized that a hypoxic state in damaged muscles may foster mrSCs activation and proliferation and trigger differentiation toward an osteogenic li

SUBMITTER: Drouin G 

PROVIDER: S-EPMC6582603 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature