High expression of metabolic enzyme PFKFB4 is associated with poor prognosis of operable breast cancer.

ABSTRACT:

Background

Enhanced glycolysis in tumors, known as the Warburg effect, provides the metabolic basis of enhanced cancer cell proliferation and metastasis. The Warburg pathway enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) is a newly identified key kinase that regulates transcriptional reprogramming and cell proliferation. Here we show the prognostic value of PFKFB4 expression in patients with operable breast cancer.

Methods

PFKFB4 expression was evaluated by immunohistochemistry in surgical specimens retrospectively collected from 200 patients with histologically proven invasive ductal breast cancer. Kaplan-Meier survival analysis and Cox regression analysis were performed to assess the prognostic significance of PFKFB4 expression.

Results

Kapla

SUBMITTER: Yao L 

PROVIDER: S-EPMC6582605 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature