Association of Key Genes and Pathways with Atopic Dermatitis by Bioinformatics Analysis.

ABSTRACT: BACKGROUND Atopic dermatitis is a chronic inflammatory disease of the skin. It has a high prevalence worldwide and affected persons are prone to recurrent attacks, seriously affecting the physical and mental of patients. The exact etiology of the disease is still unclear. MATERIAL AND METHODS There are 7 datasets on atopic dermatitis in the Gene Expression Omnibus database, including 142 lesional and 134 non-lesional skin biopsy samples. Differential analysis was performed after datasets were integrated by robust multi-array average method. Functional modules of GSE99802 were explored by weighted gene co-expression network analysis. The 4 most important modules were enriched into the pathways by Metascape. RESULTS Significantly differentially expressed genes included 41 upregulated and 10

SUBMITTER: Zhu J 

PROVIDER: S-EPMC6582687 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature