Germline Structural Variations Are Preferential Sites of DNA Replication Timing Plasticity during Development.

ABSTRACT: The DNA replication timing program is modulated throughout development and is also one of the main factors influencing the distribution of mutation rates across the genome. However, the relationship between the mutagenic influence of replication timing and its developmental plasticity remains unexplored. Here, we studied the distribution of copy number variations (CNVs) and single nucleotide polymorphisms across the zebrafish genome in relation to changes in DNA replication timing during embryonic development in this model vertebrate species. We show that CNV sites exhibit strong replication timing plasticity during development, replicating significantly early during early development but significantly late during more advanced developmental stages. Reciprocally, genomic regions that chang

SUBMITTER: Hulke ML 

PROVIDER: S-EPMC6582765 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature