Effect of Docosahexaenoic Acid Supplementation vs Placebo on Developmental Outcomes of Toddlers Born Preterm: A Randomized Clinical Trial.

ABSTRACT:

Importance

Intake of dietary docosahexaenoic acid (DHA) among toddlers is low. Supplementation may benefit developmental outcomes of toddlers who were born preterm.

Objective

To determine whether 6 months of daily DHA supplementation improves developmental outcomes of toddlers who were born preterm.

Design, setting, and participants

A randomized, fully masked, placebo-controlled trial was conducted from April 26, 2012, to March 24, 2017, at a large US pediatric academic center with 9 neonatal intensive care units. Children born at less than 35 weeks' gestation who were 10 to 16 months corrected age underwent 6 months of intervention. Of 2363 children assessed, 982 were eligible, 605 declined, and 377 enrolled and were randomized. Analyses were according to intent to t

SUBMITTER: Keim SA 

PROVIDER: S-EPMC6583023 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature