Effect of Damaging Rare Mutations in Synapse-Related Gene Sets on Response to Short-term Antipsychotic Medication in Chinese Patients With Schizophrenia: A Randomized Clinical Trial.

ABSTRACT:

Importance

The underlying mechanism for individual differences in patient response to antipsychotic medication remains unknown.

Objective

To discover genes and gene sets harboring rare variants associated with short-term antipsychotic medication efficacy.

Design, setting, and participants

In this multicenter, open-label, randomized clinical trial conducted between July 6, 2010, and December 31, 2011, 3023 patients recruited in China of Chinese Han descent with schizophrenia with total Positive and Negative Syndrome Scale (PANSS) score ≥ 60 received a 6-week treatment of antipsychotic medications randomly chosen from 5 atypical and 2 typical antipsychotic medications. Whole-exome sequencing (WES) was performed in 316 participants (grouped into those with the best respo

SUBMITTER: Wang Q 

PROVIDER: S-EPMC6583032 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature