Association of Age at Onset and Longitudinal Course of Prefrontal Function in Youth With Schizophrenia.

ABSTRACT:

Importance

The extent of cognitive deterioration after schizophrenia (SZ) onset is poorly understood because prior longitudinal studies used small samples of older individuals with established illness.

Objective

To examine the association of age at onset and subsequent longitudinal course of prefrontal activity during the first 2 years of illness in youths with SZ and healthy control participants (HCs).

Design, setting, and participants

This naturalistic, longitudinal, functional magnetic resonance imaging (fMRI) study included patients with recent-onset SZ and HCs aged 12 to 25 years enrolled in an ongoing study of cognition in recent-onset psychosis in the Sacramento, California, area from October 13, 2004, through June 25, 2013. Participants completed clinical asse

SUBMITTER: Niendam TA 

PROVIDER: S-EPMC6583034 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature