Effect of Glyburide vs Subcutaneous Insulin on Perinatal Complications Among Women With Gestational Diabetes: A Randomized Clinical Trial.

ABSTRACT:

Importance

Randomized trials have not focused on neonatal complications of glyburide for women with gestational diabetes.

Objective

To compare oral glyburide vs subcutaneous insulin in prevention of perinatal complications in newborns of women with gestational diabetes.

Design, settings, and participants

The Insulin Daonil trial (INDAO), a multicenter noninferiority randomized trial conducted between May 2012 and November 2016 (end of participant follow-up) in 13 tertiary care university hospitals in France including 914 women with singleton pregnancies and gestational diabetes diagnosed between 24 and 34 weeks of gestation.

Interventions

Women who required pharmacologic treatment after 10 days of dietary intervention were randomly assigned to receive glyburide

SUBMITTER: Senat MV 

PROVIDER: S-EPMC6583037 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature