Association of Exfoliation Syndrome With Risk of Indirect Inguinal Hernia: The Utah Project on Exfoliation Syndrome.

ABSTRACT:

Importance

Exfoliation syndrome (XFS) is a systemic connective tissue disease, and abnormal connective tissue metabolism is implicated in inguinal hernias (IH). Associating XFS with comorbid conditions may illuminate their underlying pathophysiology and affect clinical screening and treatment. Exfoliation syndrome involves altered systemic extracellular matrix (ECM) homeostasis involving elastin metabolism. Hernias occur owing to abnormal ECM synthesis, metabolism, or repair. Inguinal hernias involve weakening or rupture of the abdominal/groin wall.

Objective

To determine an association between patients with XFS and patients with IH in Utah, possibly differing between direct or indirect hernia.

Design, setting, and participants

Cross-sectional study in a large health

SUBMITTER: Besch BM 

PROVIDER: S-EPMC6583040 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature