Association Between Oxygen Saturation Targeting and Death or Disability in Extremely Preterm Infants in the Neonatal Oxygenation Prospective Meta-analysis Collaboration.

ABSTRACT:

Importance

There are potential benefits and harms of hyperoxemia and hypoxemia for extremely preterm infants receiving more vs less supplemental oxygen.

Objective

To compare the effects of different target ranges for oxygen saturation as measured by pulse oximetry (Spo2) on death or major morbidity.

Design, setting, and participants

Prospectively planned meta-analysis of individual participant data from 5 randomized clinical trials (conducted from 2005-2014) enrolling infants born before 28 weeks' gestation.

Exposures

Spo2 target range that was lower (85%-89%) vs higher (91%-95%).

Main outcomes and measures

The primary outcome was a composite of death or major disability (bilateral blindness, deafness, cerebral palsy diagnosed as ≥2 level on the Gross Mo

SUBMITTER: Askie LM 

PROVIDER: S-EPMC6583054 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature