Effect of Depth of Sedation in Older Patients Undergoing Hip Fracture Repair on Postoperative Delirium: The STRIDE Randomized Clinical Trial.

ABSTRACT:

Importance

Postoperative delirium is the most common complication following major surgery in older patients. Intraoperative sedation levels are a possible modifiable risk factor for postoperative delirium.

Objective

To determine whether limiting sedation levels during spinal anesthesia reduces incident delirium overall.

Design, setting, and participants

This double-blind randomized clinical trial (A Strategy to Reduce the Incidence of Postoperative Delirum in Elderly Patients [STRIDE]) was conducted from November 18, 2011, to May 19, 2016, at a single academic medical center and included a consecutive sample of older patients (≥65 years) who were undergoing nonelective hip fracture repair with spinal anesthesia and propofol sedation. Patients were excluded for preoper

SUBMITTER: Sieber FE 

PROVIDER: S-EPMC6583071 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature