Epigenetic Hallmarks of Fetal Early Atherosclerotic Lesions in Humans.

ABSTRACT:

Importance

Although increasingly strong evidence suggests a role of maternal total cholesterol and low-density lipoprotein cholesterol (LDLC) levels during pregnancy as a risk factor for atherosclerotic disease in the offspring, the underlying mechanisms need to be clarified for future clinical applications.

Objective

To test whether epigenetic signatures characterize early fetal atherogenesis associated with maternal hypercholesterolemia and to provide a quantitative estimate of the contribution of maternal cholesterol level to fetal lesion size.

Design, setting, and participants

This autopsy study analyzed 78 human fetal aorta autopsy samples from the Division of Human Pathology, Department of Advanced Biomedical Sciences, Federico II University of Naples, Naples, I

SUBMITTER: de Nigris F 

PROVIDER: S-EPMC6583096 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature