Association of Leucine-Rich Glioma Inactivated Protein 1, Contactin-Associated Protein 2, and Contactin 2 Antibodies With Clinical Features and Patient-Reported Pain in Acquired Neuromyotonia.

ABSTRACT:

Importance

Although acquired autoimmune neuromyotonia (NMT) is associated with voltage-gated potassium channel (VGKC)-complex antibodies, to date there has been no systematic study of autoantibodies to the specific antigens leucine-rich glioma inactivated protein 1 (LGI1), contactin-associated protein 2 (CASPR2), and contactin 2 together with the full clinical syndrome, particularly pain and autonomic and central nervous system involvement.

Objectives

To study the full spectrum of clinical features and serum autoantibodies in patients with NMT, including the effects of pain on quality of life.

Design, setting, and participants

A cohort study of clinical features and serologic testing in 38 patients with electrophysiologically-confirmed NMT, reviewed clinically between

SUBMITTER: Vincent A 

PROVIDER: S-EPMC6583195 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature