Effect of Vitamin D Supplementation on Recurrent Wheezing in Black Infants Who Were Born Preterm: The D-Wheeze Randomized Clinical Trial.

ABSTRACT:

Importance

Black infants born preterm face high rates of recurrent wheezing throughout infancy. Vitamin D supplementation has the potential to positively or negatively affect wheezing through modulation of the pulmonary and immune systems.

Objective

To assess the effectiveness of 2 vitamin D dosing strategies in preventing recurrent wheezing.

Design, setting, and participants

A randomized clinical trial enrolled 300 black infants born at 28 to 36 weeks' gestation between January 2013 and January 2016 at 4 sites in the United States, and followed them up through March 2017. Randomization was stratified by site and maternal milk exposure.

Interventions

Patients were enrolled prior to discharge from the neonatal intensive care unit or newborn nursery and received

SUBMITTER: Hibbs AM 

PROVIDER: S-EPMC6583240 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature