Assessment of Reported Comparative Effectiveness and Safety of Atypical Antipsychotics in the Treatment of Behavioral and Psychological Symptoms of Dementia: A Network Meta-analysis.

ABSTRACT:

Importance

Atypical antipsychotics offer modest effectiveness compared with placebo but with serious safety risks, including a boxed warning for the risk of death in the treatment of behavioral and psychological symptoms of dementia (BPSD). Their comparative effectiveness and safety are not fully known.

Objective

To assess the relative benefits and safety of atypical antipsychotics in the treatment of BPSD shown in randomized clinical trials using network meta-analysis.

Data sources

PubMed/MEDLINE, Embase, PsychINFO, and Cochrane Library were searched from their inception until May 31, 2018. Key terms included dementia and atypical antipsychotics.

Study selection

Randomized clinical trials comparing any atypical antipsychotic with another atypical antipsychotic

SUBMITTER: Yunusa I 

PROVIDER: S-EPMC6583313 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature