Influence of Surgical Procedures and General Anesthesia on Child Development Before Primary School Entry Among Matched Sibling Pairs.

ABSTRACT:

Importance

Substantial preclinical evidence suggests that the developing brain is susceptible to injury from anesthetic drugs. Findings from clinical studies of the neurotoxic effects of anesthesia are mixed, but these effects can be influenced by unmeasured confounding from biological and environmental risk and protective factors on child development.

Objective

To examine the association between surgical procedures that require general anesthesia before primary school entry and child development in biological siblings.

Design, setting, and participants

This retrospective sibling-matched cohort study included sibling pairs aged 5 to 6 years with the same birth mother who had Early Development Instrument (EDI) data completed. The EDI is a population-based measure of ch

SUBMITTER: O'Leary JD 

PROVIDER: S-EPMC6583453 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature