Benefits and Harms of Antihypertensive Treatment in Low-Risk Patients With Mild Hypertension.

ABSTRACT:

Importance

Evidence to support initiation of pharmacologic treatment in low-risk patients with mild hypertension is inconclusive, with previous trials underpowered to demonstrate benefit. Clinical guidelines across the world are contradictory.

Objective

To examine whether antihypertensive treatment is associated with a low risk of mortality and cardiovascular disease (CVD) in low-risk patients with mild hypertension.

Design, setting, and participants

In this longitudinal cohort study, data were extracted from the Clinical Practice Research Datalink, from January 1, 1998, through September 30, 2015, for patients aged 18 to 74 years who had mild hypertension (untreated blood pressure of 140/90-159/99 mm Hg) and no previous treatment. Anyone with a history of CVD or CVD

SUBMITTER: Sheppard JP 

PROVIDER: S-EPMC6583613 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature