Association of Acute Kidney Injury With Concomitant Vancomycin and Piperacillin/Tazobactam Treatment Among Hospitalized Children.

ABSTRACT:

Importance

β-Lactam antibiotics are often coadministered with intravenous (IV) vancomycin hydrochloride for children with suspected serious infections. For adults, the combination of IV vancomycin plus piperacillin sodium/tazobactam sodium is associated with a higher risk of acute kidney injury (AKI) compared with vancomycin plus 1 other β-lactam antibiotic. However, few studies have evaluated the safety of this combination for children.

Objective

To assess the risk of AKI in children during concomitant therapy with vancomycin and 1 antipseudomonal β-lactam antibiotic throughout the first week of hospitalization.

Design, setting, and participants

This retrospective cohort study focused on children hospitalized for 3 or more days who received IV vancomycin plus 1 other

SUBMITTER: Downes KJ 

PROVIDER: S-EPMC6583633 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature