Association Between Early Life Adversity and Risk for Poor Emotional and Physical Health in Adolescence: A Putative Mechanistic Neurodevelopmental Pathway.

ABSTRACT:

Importance

Adverse childhood experiences (ACEs) have been associated with poor mental and physical health outcomes. However, the mechanism of this effect, critical to enhancing public health, remains poorly understood.

Objective

To investigate the neurodevelopmental trajectory of the association between early ACEs and adolescent general and emotional health outcomes.

Design, setting, and participants

A prospective longitudinal study that began when patients were aged 3 to 6 years who underwent neuroimaging later at ages 7 to 12 years and whose mental and physical health outcomes were observed at ages 9 to 15 years. Sequential mediation models were used to investigate associations between early ACEs and brain structure, emotion development, and health outcomes longitud

SUBMITTER: Luby JL 

PROVIDER: S-EPMC6583637 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature