Opioids for Chronic Noncancer Pain: A Systematic Review and Meta-analysis.

ABSTRACT:

Importance

Harms and benefits of opioids for chronic noncancer pain remain unclear.

Objective

To systematically review randomized clinical trials (RCTs) of opioids for chronic noncancer pain.

Data sources and study selection

The databases of CENTRAL, CINAHL, EMBASE, MEDLINE, AMED, and PsycINFO were searched from inception to April 2018 for RCTs of opioids for chronic noncancer pain vs any nonopioid control.

Data extraction and synthesis

Paired reviewers independently extracted data. The analyses used random-effects models and the Grading of Recommendations Assessment, Development and Evaluation to rate the quality of the evidence.

Main outcomes and measures

The primary outcomes were pain intensity (score range, 0-10 cm on a visual analog scale for pain;

SUBMITTER: Busse JW 

PROVIDER: S-EPMC6583638 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature