Brain Heterogeneity in Schizophrenia and Its Association With Polygenic Risk.

ABSTRACT:

Importance

Between-individual variability in brain structure is determined by gene-environment interactions, possibly reflecting differential sensitivity to environmental and genetic perturbations. Magnetic resonance imaging (MRI) studies have revealed thinner cortices and smaller subcortical volumes in patients with schizophrenia. However, group-level comparisons may mask considerable within-group heterogeneity, which has largely remained unnoticed in the literature.

Objectives

To compare brain structural variability between individuals with schizophrenia and healthy controls and to test whether respective variability reflects the polygenic risk score (PRS) for schizophrenia in an independent sample of healthy controls.

Design, setting, and participants

This case-con

SUBMITTER: Alnæs D 

PROVIDER: S-EPMC6583664 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature