Association of Depression With Risk of Incident Systemic Lupus Erythematosus in Women Assessed Across 2 Decades.

ABSTRACT:

Importance

It has long been hypothesized that depression may increase the risk of developing autoimmune disease; however, rigorous empirical evidence is sparse.

Objective

To evaluate whether an association exists between depression and risk of incident systemic lupus erythematosus (SLE), a paradigmatic, systemic autoimmune disease.

Design, setting, and participants

This 20-year prospective, longitudinal cohort study evaluated data collected from 2 cohorts of women participating in the Nurses' Health Study (1996-2012) and the Nurses' Health Study II (1993-2013). Data analyses were conducted from August 2017 to May 2018.

Main outcomes and measures

Incident SLE with 4 or more American College of Rheumatology criteria was ascertained by self-report and confirmed by

SUBMITTER: Roberts AL 

PROVIDER: S-EPMC6583686 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature