Association of Stress-Related Disorders With Subsequent Autoimmune Disease.

ABSTRACT:

Importance

Psychiatric reactions to life stressors are common in the general population and may result in immune dysfunction. Whether such reactions contribute to the risk of autoimmune disease remains unclear.

Objective

To determine whether there is an association between stress-related disorders and subsequent autoimmune disease.

Design, setting, and participants

Population- and sibling-matched retrospective cohort study conducted in Sweden from January 1, 1981, to December 31, 2013. The cohort included 106 464 exposed patients with stress-related disorders, with 1 064 640 matched unexposed persons and 126 652 full siblings of these patients.

Exposures

Diagnosis of stress-related disorders, ie, posttraumatic stress disorder, acute stress reaction, adjustment

SUBMITTER: Song H 

PROVIDER: S-EPMC6583688 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature