Association of Intrathecal Immunoglobulin G Synthesis With Disability Worsening in Multiple Sclerosis.

ABSTRACT:

Importance

Reliable biomarkers associated with disability worsening in multiple sclerosis (MS) are still needed.

Objective

To determine a possible association of intrathecal IgG synthesis and early disability worsening as measured by Expanded Disability Status Scale (EDSS) scoring in patients with relapsing-remitting MS or clinically isolated syndrome.

Design, setting, and participants

Cerebrospinal fluid measurements and clinical data from the observational longitudinal German national multiple sclerosis cohort were analyzed. Patients were recruited between August 2010 and November 2015 from 18 centers. Data analysis was completed from August 2018 to December 2018.

Exposure

Patients were offered standard immunotherapies per national treatment guidelines.

Ma

SUBMITTER: Gasperi C 

PROVIDER: S-EPMC6583696 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature