Effect of Prefrontal Cortex Stimulation on Regulation of Amygdala Response to Threat in Individuals With Trait Anxiety: A Randomized Clinical Trial.

ABSTRACT:

Importance

Transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC) is under clinical investigation as a treatment for major depressive disorder. However, the mechanisms of action are unclear, and there is a lack of neuroimaging evidence, particularly among individuals with affective dysfunction. Furthermore, there is no direct causal evidence among humans that the prefrontal-amygdala circuit functions as described in animal models (ie, that increasing activity in prefrontal cortical control regions inhibits amygdala response to threat).

Objective

To determine whether stimulation of the prefrontal cortex reduces amygdala threat reactivity in individuals with trait anxiety.

Design, setting, and participants

This community-based rando

SUBMITTER: Ironside M 

PROVIDER: S-EPMC6583758 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature