Clinical and molecular characterization of early-onset colorectal cancer.

ABSTRACT:

Background

Colorectal cancer (CRC) incidence is increasing in adults younger than 50 years. This study evaluated clinical and molecular features to identify those features unique to early-onset CRC that differentiate these patients from patients 50 years old or older.

Methods

Baseline characteristics were evaluated according to the CRC onset age with 3 independent cohorts. A fourth cohort was used to describe the impact of age on the consensus molecular subtype (CMS) prevalence.

Results

This retrospective review of more than 36,000 patients with CRC showed that early-onset patients were more likely to have microsatellite instability (P = .038), synchronous metastatic disease (P = .009), primary tumors in the distal colon or rectum (P < .0001), and fewer BRAF V600 muta

SUBMITTER: Willauer AN 

PROVIDER: S-EPMC6583775 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature