BCScreen: A gene panel to test for breast carcinogenesis in chemical safety screening.

ABSTRACT: Targeted gene lists have been used in clinical settings to specify breast tumor type, and to predict breast cancer prognosis and response to treatment. Separately, panels have been curated to predict systemic toxicity and xenoestrogen activity as a part of chemical screening strategies. However, currently available panels do not specifically target biological processes relevant to breast development and carcinogenesis. We have developed a gene panel called the Breast Carcinogen Screen (BCScreen) as a tool to identify potential breast carcinogens and characterize mechanisms of toxicity. First, we used four seminal reviews to identify 14 key characteristics of breast carcinogenesis, such as apoptosis, immunomodulation, and genotoxicity. Then, using a hybrid data and knowledge-driven framewor

SUBMITTER: Grashow RG 

PROVIDER: S-EPMC6583811 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature