Association of Rare Copy Number Variants With Risk of Depression.

ABSTRACT:

Importance

The role of large, rare copy number variants (CNVs) in neuropsychiatric disorders is well established, but their association with common psychiatric disorders, such as depression, remains unclear.

Objective

To examine the association of a group of 53 CNVs associated with neurodevelopmental disorders and burden of rare CNVs with risk of depression.

Design, setting, and participants

This case-control study used data from the UK Biobank study sample, which comprised 502 534 individuals living in the United Kingdom. Individuals with autism spectrum disorder, intellectual disability, attention-deficit/hyperactivity disorder, schizophrenia, or bipolar affective disorder diagnoses were excluded. Analyses were further restricted to individuals of European genetic a

SUBMITTER: Kendall KM 

PROVIDER: S-EPMC6583866 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature