A Swedish Nationwide Adoption Study of the Heritability of Heart Failure.

ABSTRACT:

Importance

Heart failure (HF) aggregates in families, but the heritability of HF has not been determined. Discerning the genetic and environmental contributions to HF risk is important to further helping to identify individuals at risk. Adoption studies may establish the genetic contribution to HF.

Objective

This nationwide adoption study aimed to determine the heritability of HF.

Design, setting, and participants

This case-control study and cohort study design used logistic regression for calculating risks of HF in adoptees. Adoptees who were born in Sweden between 1942 and 1990 were linked to their adoptive parents and biological parents. The Swedish Multi-Generation Register was linked to the Swedish Patient Register for information on hospital inpatient and outpat

SUBMITTER: Lindgren MP 

PROVIDER: S-EPMC6583873 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature