Association Between Changes in Body Composition and Neoadjuvant Treatment for Pancreatic Cancer.

ABSTRACT: Importance:Sarcopenia and sarcopenic obesity have been associated with poor outcomes in unresectable pancreatic cancer (PC). Neoadjuvant treatment (NT) is used increasingly to improve resectability; however, its effects on fat and muscle body composition have not been characterized. Objectives:To evaluate whether NT affects muscle mass and adipose tissue in patients with borderline resectable PC (BRPC) and locally advanced PC (LAPC) and determine whether there were potential differences between patients who ultimately underwent resection and those who did not. Design, Setting, and Participants:In this retrospective cohort study conducted at 4 academic medical centers, 193 patients with BRPC and LAPC undergoing surgical exploration after NT who had available computed tomographic scans (both

SUBMITTER: Sandini M 

PROVIDER: S-EPMC6583880 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature