Greater progression of coronary artery calcification is associated with clinically relevant cognitive impairment in type 1 diabetes.

ABSTRACT:

Background and aims

We assessed the predictive role of coronary artery calcification (CAC) in clinically relevant cognitive impairment in 148 middle-aged individuals with childhood-onset type 1 diabetes (T1D) from the Pittsburgh Epidemiology of Diabetes Complications (EDC) Study.

Methods

Baseline CAC was measured in 1996-98 and repeated 4-8 years later. Per extensive neuropsychological testing in 2010-15, 28% (41/148) of participants met the study definition of clinically relevant cognitive impairment (two or more of 7 select test scores ≥1.5SD worse than demographically appropriate published norms). Logistic regression models with backward selection were constructed for statistical analysis.

Results

Mean age and T1D duration at first CAC measure were 37 and 29 years,

SUBMITTER: Guo J 

PROVIDER: S-EPMC6584032 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature