The 9p21 coronary artery disease locus and kidney dysfunction in patients with Type 2 diabetes mellitus.

ABSTRACT:

Background

We investigated whether the coronary artery disease (CAD) locus on chromosome 9p21 (as represented by single nucleotide polymorphism rs2383206) is associated with low estimated glomerular filtration rate (eGFR) or increased urinary albumin excretion in patients with Type 2 diabetes mellitus (T2DM).

Methods

Four samples, including a total of 3167 patients, were studied. The presence of low eGFR (<60 mL/min/1.73m(2)) was estimated from serum creatinine by means of the Modification of Diet in Renal Disease Study equation. Increased urinary albumin excretion was defined as an albumin-creatinine ratio (ACR) ≥2.5 mg/mmol in men and ≥3.5 mg/mmol in women.

Results

No association was found between rs2383206 and low eGFR or increased ACR in each sample as well as in

SUBMITTER: De Cosmo S 

PROVIDER: S-EPMC6584132 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature