Metformin Improves Peripheral Insulin Sensitivity in Youth With Type 1 Diabetes.

ABSTRACT:

Context

Type 1 diabetes in adolescence is characterized by insulin deficiency and insulin resistance (IR), both thought to increase cardiovascular disease risk. We previously demonstrated that adolescents with type 1 diabetes have adipose, hepatic, and muscle IR, and that metformin lowers daily insulin dose, suggesting improved IR. However, whether metformin improves IR in muscle, hepatic, or adipose tissues in type 1 diabetes was unknown.

Objective

Measure peripheral, hepatic, and adipose insulin sensitivity before and after metformin or placebo therapy in youth with obesity with type 1 diabetes.

Design

Double-blind, placebo-controlled clinical trial.

Setting

Multi-center at eight sites of the T1D Exchange Clinic Network.

Participants

A subset of 12- to

SUBMITTER: Cree-Green M 

PROVIDER: S-EPMC6584133 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature