Association of Quantitative Metastatic Lymph Node Burden With Survival in Hypopharyngeal and Laryngeal Cancer.

ABSTRACT: Importance:Nodal staging for laryngohypopharyngeal cancers is based primarily on size and laterality, with less value placed on absolute number of metastatic lymph nodes (LNs). We are aware of no studies to date that have specifically addressed the prognostic effect of quantitative nodal burden in larynx or hypopharynx malignancies. Objective:To assess the independent impact of quantitative metastatic LN burden on mortality risk. Design, Setting, and Participants:Univariate and multivariable models were constructed to evaluate the association between patients' number of metastatic LNs and their survival, adjusting for factors such as nodal size, laterality, extranodal extension, margin status, and adjuvant treatment. Participants were patients with squamous cell carcinoma of the larynx or

SUBMITTER: Ho AS 

PROVIDER: S-EPMC6584272 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature