Efficacy of 42 Pharmacologic Cotreatment Strategies Added to Antipsychotic Monotherapy in Schizophrenia: Systematic Overview and Quality Appraisal of the Meta-analytic Evidence.

ABSTRACT:

Importance

Limited treatment responses in schizophrenia prompted the testing of combining an antipsychotic drug treatment with a second psychotropic medication. A comprehensive evaluation of the efficacy of multiple medication combinations is missing.

Objective

To summarize and compare the meta-analytically determined efficacy of pharmacologic combination strategies of antipsychotic drugs in adults with schizophrenia.

Data sources

Systematic search of PubMed and PsycInfo until May 13, 2016.

Study selection

Meta-analyses of randomized clinical trials comparing the efficacy of antipsychotic drugs combined with other antipsychotic or nonantipsychotic medications vs placebos or antipsychotic monotherapy among adults with schizophrenia.

Data extraction and synthe

SUBMITTER: Correll CU 

PROVIDER: S-EPMC6584320 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature