HLA Polymorphisms And TKI-Induced Liver Injury in Patients with Cancer: A Meta-analysis.

ABSTRACT: Background: Tyrosine kinase inhibitors (TKIs) are widely used for patients with cancer, although liver injury has been observed in a small proportion of these patients. The aim of this study was to investigate the mechanisms underlying TKI-induced liver injury according to HLA polymorphisms. Methods: We systematically searched three electronic databases (PubMed, PMC, EmBase, and the Cochrane library) to identify studies that evaluated the impact of HLA polymorphisms on the incidence of TKI-induced liver injury in cancer patients as of November 2018. The summary odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a random-effects model. Further, sensitivity analysis and publication bias assessments were also performed. Results: In the final analysis, four studies tha

SUBMITTER: Xiang Q 

PROVIDER: S-EPMC6584402 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature