FAM83D promotes ovarian cancer progression and its potential application in diagnosis of invasive ovarian cancer.

ABSTRACT: Although invasive epithelial ovarian cancer (IOC) and low malignant potential ovarian tumour (LMP) are similar, they are associated with different outcomes and treatment strategies. The current accuracy in distinguishing these diseases is unsatisfactory, leading to delays or unnecessary treatments. We compared the molecular signature of IOC and LMP cases by analysing their transcriptomic data and re-clustered them according to these data rather than the pathological dissection. We identified that FAM83D was highly expressed in IOC. To verify the role of FAM83D in the progression and metastasis, we used the isogenic ovarian cancer metastatic models, highly metastatic cells (HM) and non-metastatic cells (NM). Overexpression of FAM83D significantly promoted cell proliferation, migration and s

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC6584551 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature