Screening by changes in stereotypical behavior during cell motility.

ABSTRACT: Stereotyped behaviors are series of postures that show very little variability between repeats. They have been used to classify the dynamics of individuals, groups and species without reference to the lower-level mechanisms that drive them. Stereotypes are easily identified in animals due to strong constraints on the number, shape, and relative positions of anatomical features, such as limbs, that may be used as landmarks for posture identification. In contrast, the identification of stereotypes in single cells poses a significant challenge as the cell lacks these landmark features, and finding constraints on cell shape is a non-trivial task. Here, we use the maximum caliber variational method to build a minimal model of cell behavior during migration. Without reference to biochemical deta

SUBMITTER: Tweedy L 

PROVIDER: S-EPMC6584642 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature