The antifungal potential of (Z)-ligustilide and the protective effect of eugenol demonstrated by a chemometric approach.

ABSTRACT: Mankind is on the verge of a postantibiotic era. New concepts are needed in our battle to attenuate infectious diseases around the world and broad spectrum plant-inspired synergistic pharmaceutical preparations should find their place in the global fight against pathogenic microorganisms. To progress towards the discovery of potent antifungal agents against human pathologies, we embarked upon developing chemometric approach coupled with statistical design to unravel the origin of the anticandidal potential of a set of 66 essential oils (EOs). EOs were analyzed by GC-MS and tested against Candida albicans and C. parapsilosis (Minimal Inhibitory Concentration, MIC). An Orthogonal Partial Least Square (OPLS) analysis allowed us to identify six molecules presumably responsible for the anticand

SUBMITTER: Rodrigues AMS 

PROVIDER: S-EPMC6584663 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature