Progressive expression of PPARGC1α is associated with hair miniaturization in androgenetic alopecia.

ABSTRACT: Current opinion views androgens as the pathogenic driver in the miniaturization of hair follicles of androgenetic alopecia by interfering with the dermal papilla. This cannot be the sole cause and therefore it is important for therapeutic and diagnostic purposes to identify additional pathways. Comparative full transcriptome profile analysis of the hair bulb region of normal and miniaturized hair follicles from vertex and occipital region in males with and without androgenetic alopecia revealed that next to the androgen receptor as well the retinoid receptor and particularly the PPAR pathway is involved in progressive hair miniaturization. We demonstrate the concurrent up-regulation of PPARGC1a in the epithelial compartment and androgen receptor in the dermal papilla of miniaturized hair.

SUBMITTER: Ho BS 

PROVIDER: S-EPMC6584672 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature