Mathematical modeling of sleep state dynamics in a rodent model of shift work.

ABSTRACT: Millions of people worldwide are required to work when their physiology is tuned for sleep. By forcing wakefulness out of the body's normal schedule, shift workers face numerous adverse health consequences, including gastrointestinal problems, sleep problems, and higher rates of some diseases, including cancers. Recent studies have developed protocols to simulate shift work in rodents with the intention of assessing the effects of night-shift work on subsequent sleep (Grønli et al., 2017). These studies have already provided important contributions to the understanding of the metabolic consequences of shift work (Arble et al., 2015; Marti et al., 2016; Opperhuizen et al., 2015) and sleep-wake-specific impacts of night-shift work (Grønli et al., 2017). However, our understanding of the caus

SUBMITTER: Rempe MJ 

PROVIDER: S-EPMC6584688 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature